<i>TP53</i> Codon 72 Polymorphism Is Associated with Coronary Artery Disease in Chilean Subjects
نویسندگان
چکیده
منابع مشابه
p53 codon 72 polymorphism and coronary artery disease: Evidence of interaction with ACP1
BACKGROUND Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is as...
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OBJECTIVE To investigate the possible association between factor XII (F12) gene variant and the presence of coronary artery disease (CAD) in Chilean subjects. METHODS A total of 112 unrelated patients with a diagnosis of CAD confirmed by angiography (33-74 years old) and 107 healthy controls (30-68 years old) were included in this study. PCR-RFLP was used to evaluate the 46C --> T polymorphis...
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متن کاملTP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers.
Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effects of this polymorphism on pancreatic cancer in relation to smoking and drinkin...
متن کاملPrimary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism
PURPOSE Apoptosis has been implicated as the mechanism for retinal ganglion cell death in primary open-angle glaucoma (POAG), a complex neurodegenerative disease. There have been inconsistent reports regarding increased risk of POAG and a polymorphism (Arg72Pro) within the tumor suppressor gene, p53. The goal of this study was to examine the role of this polymorphism in susceptibility to POAG i...
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ژورنال
عنوان ژورنال: Medical Principles and Practice
سال: 2011
ISSN: 1423-0151,1011-7571
DOI: 10.1159/000321206